Enzyme Inhibitor Development Using Metal-Organic Framework Technology: Therapeutic and Agricultural Potential

Liang Chen

doi:10.71222/5fgxms43

Authors

Liang Chen Shenyang University, Liaoning, China Author

DOI:

https://doi.org/10.71222/5fgxms43

Keywords:

metal-organic frameworks, enzyme inhibitors, therapeutic applications, agricultural biotechnology, drug delivery, biosensors

Abstract

Metal-organic frameworks (MOFs) have emerged as revolutionary platforms for enzyme inhibitor development, offering unprecedented opportunities in both therapeutic and agricultural applications. These crystalline porous materials, composed of metal nodes connected by organic linkers, provide unique structural properties that enable precise control over enzyme-inhibitor interactions. The high surface area, tunable pore sizes, and customizable chemical environments of MOFs facilitate the design of highly selective and efficient enzyme inhibitors. In therapeutic applications, MOF-based enzyme inhibitors show remarkable potential for treating various diseases by targeting specific enzymatic pathways while minimizing off-target effects. Agricultural applications demonstrate significant promise in developing environmentally sustainable enzyme inhibitors for pest control and crop protection. The versatility of MOF platforms allows for the incorporation of multiple inhibitory mechanisms within a single framework, enhancing overall efficacy. Recent advances in MOF synthesis and functionalization have enabled the development of stimuli-responsive inhibitor systems that can be activated under specific conditions. This comprehensive review examines the current state of MOF-based enzyme inhibitor development, highlighting key breakthroughs in design strategies, synthesis methodologies, and practical applications. The integration of computational modeling with experimental validation has accelerated the discovery of novel inhibitor-MOF combinations with enhanced selectivity and potency.

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